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When Combination Therapy Should Not Be Used Using both medicines together may not be appropriate if: The patient has kidney stones, severe depression, eating disorders, or glaucoma (Topiramate concerns) The patient has a history of pancreatitis, severe gastrointestinal disease, or certain thyroid conditions (semaglutide concerns) The person is pregnant or planning pregnancy Side effects become too strong when both medicines are used The patient cannot attend regular follow-up appointments In these cases, a single medication or a different treatment plan may be safer

TABLE 2 Clinical outcomes of the selected cohort under investigation

Its not approved for the treatment of type 2 diabetes

Lowering your dose could make it harder to keep blood sugar levels in range, which is why Hatipoglu says dose reductions should be guided by a healthcare professional

Extreme fatigue or confusion