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This would render oral formulations of DSIP virtually ineffective compared to nasal spray and injections [5]
At the cellular level, under hypoxic conditions, the hypoxiainducible factor (HIF)prolyl hydroxylase family of enzymes (PHD13) lose their ability to hydroxylate HIF because they rely on O 2 for their enzymatic activity [139]
Peptides 13(1):1316 Sandoval DA, DAlessio DA (2015) Physiology of proglucagon peptides: role of glucagon and GLP-1 in health and disease
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