While the intravenous (IV) route has historically been the most widely used, the subcutaneous (SC) route is now accepted and presented as safe and effective, whether in the context of chronic disease or in palliative care
Pflugers Arch 442:28696 Sato H, Shiiya A, Kimata M, Maebara K, Tamba M, Sakakura Y, Makino N, Sugiyama F, Yagami K, Moriguchi T, Takahashi S, Bannai S (2005) Redox imbalance in cystine/glutamate transporter-deficient mice
And here we're talking about FDA approved, clinically tested peptides, but in many cases they've been clinically tested for one particular area of medicine
2007 in the New England Journal of Medicine (NCT00123253, n = 412 HIV-infected adults, 2:1 tesamorelin to placebo, 26-week primary phase) met its pre-specified visceral-adipose-tissue primary endpoint by CT versus placebo, with concurrent IGF-1 elevation from baseline [6]
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