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This was followed by a 6-week washout period
Daily movement, hydration, and consistency with meals further influence outcomes
Observational evidence further supports a context-dependent effect of metformin, as data from the National Alzheimers Coordinating Center database found that metformin use was associated with improved memory performance, but this benefit was not observed in APOE-4 carriers 90 , suggesting that metformin may be protective in individuals with DM2 but not in those with certain genetic predisposition factors for AD, such as APOE-4, which is the strongest genetic risk factor for sporadic AD 91
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Learn about the pros and cons of enterically coated supplements, including ingredient absorption,safety and price
