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That threshold appears without a source or a time frame, so it reads as the article's own framing rather than an established clinical cutoff
Choose too much water and higher doses become impractically large volumes
Higher risk in heart/kidney disease or with diuretics/ACE inhibitors
By activating melanocortin receptors, Melanotan 2 enhances melanin production while also supporting appetite control and overall skin pigmentation balance
While this mechanism remains speculative, the underlying physiology of cryotherapy-induced blood flow changes supports the concept
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