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As a result, prophylactic treatments for migraine that target brain energy metabolism, including riboflavin, coenzyme Q10, alpha-lipoic acid (ALA), and ketogenic diet (KD), have gained increasing attention (Table 1)

GPCRs promote the differentiation of regulatory T cells (Tregs) by activating mTOR and inhibiting the histone deacetylase (HDAC) pathway (169)