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doi: 10.1111/dom.13494 81 JungSYKimJSChoiIYLeeGHKimYHKangJHet al

Rare (high doses): mild nausea, cramping, diarrhea

Similarly, patients with active malignancy warrant careful consideration given theoretical concerns about angiogenic effects potentially affecting tumor growth, though preclinical evidence suggests context-dependent effects that may inhibit rather than promote tumor angiogenesis