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A phase 2 study in subjects having BMI 27 kg/m 2 without T2D finds a mean body weight loss ranging from 9.4% to 14.7% across four doses (12, 24, 36, or 45 mg), versus 2.3% with placebo at 36 weeks ( 2 , orforglipron at the maximum dose of 45 mg produces a statistically significant glycated hemoglobin (HbA1c) reduction of 2.1%, versus 0.4% with placebo and 1.1% with dulaglutide 1.5 mg ( Results from the 40-week phase 3 ACHIEVE-1 trial in participants with obesity and poorly controlled T2D shows mean weight loss of 4.7%, 6.1%, 7.9% and 1.6% for groups receiving 3 mg, 12 mg, 36 mg, and placebo, respectively ( 3.1.2.2 Aleniglipron (GSBR-1290) Aleniglipron is an oral small molecule GLP-1 RA

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19 A separate meta-analysis of 4 major clinical trials suggested prolonged use of GLP-1RA was associated with an elevated risk of rapidly worsening DR