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Among patients without CKD, minimal increases in serum creatinine were observed for patients on a GLP-1 compared to those who were not prescribed a GLP-1: 0.01 mg/dL for semaglutide, 0.01 mg/dL for liraglutide, and 0.02 mg/dL for tirzepatide
Tirzepatide compounded with B12 will have a pink or reddish tint from the B12, so this test applies primarily to plain tirzepatide formulations
Important safety considerations for tirzepatide include its boxed warning for thyroid C-cell tumors (contraindicated in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2), risk of pancreatitis, gallbladder disease, and potential complications in patients with diabetic retinopathy
Practical Tips for Starting Retatrutide Safely Safe initiation requires full injection training, correct storage, eating a light low-fat meal before injecting, rotating injection sites, and informing your GP and all treating clinicians that you are commencing retatrutide
Serious Pancreatic Risk: Pancreatitis Acute pancreatitis has been reported rarely in users using tirzepatide
