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Consistent with the role of cholesterol in the regulation of membrane dynamics, cholesterol loading in mitochondrial membrane results in increased membrane order parameter and in the reduction in the activity of specific membrane carriers, i B via c-SRC and oxidant-dependent cell death

Method: Estimate efficacy of earlier (first add-on) AMT DR/ER use by evaluating PD diary data from pooled pivotal trials for 2 participant subgroups: 1) using levodopa monotherapy at baseline, or 2) 5 years since PD diagnosis at baseline