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In vitro cell models of the BBB offer many advantages such as the ability to test the effects of molecules on specific cell types in a high throughput manner, and to investigate several cellular mechanisms simultaneously and repetitively [120]

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Experimental vascular studies using isolated rat aorta preparations reported that BPC-157 modulated vasomotor tone and increased nitric oxide generation through activation of the SrcCaveolin-1endothelial nitric oxide synthase (eNOS) signaling pathway [3]

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