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Figure 8 3.5 Chronic fatigue syndrome (CFS) A growing body of clinical evidence shows that the gut microbiota plays a critical role in CFS, with consistently observed reductions in butyrate-producing bacteria and enrichment of Enterobacteriaceae , together with frequent depletion of anti-inflammatory taxa such as Faecalibacterium (Knig et al., 2021

At the same time , research focuses on understanding how microcirculatory processes integrate with broader tissue-level signaling networks

Leal MC, Casabona JC, Puntel M, Pitossi FJ

Therapeutic interventions include pharmacologic agents, dietary and lifestyle changes, probiotics, antibiotics, fecal microbial transplant, and stress management

Flavonoids can form complexes of proteins by both nonspecific mechanisms such as hydrogen bonding and hydrophobic effects, as well as with covalent bond formation