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the liver generates it
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The cyclic structure is maintained by the disulfide bond, which is susceptible to oxidative cleavage in the presence of dissolved oxygen, light exposure, and temperatures above 8C
Melatonin production declines with aging [34], possibly due to age-related calcification of the pineal gland [35], rather than increased clearance [34]
Nontargeted identification of reactive metabolite protein adducts
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