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A report published in November by KFF, a health information nonprofit that includes KFF Health News, found only 13 states were covering GLP-1s for the treatment of obesity for Medicaid beneficiaries as of August

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Semaglutide works by: Stimulating insulin secretion from pancreatic beta cells in a glucose-dependent manner (meaning it only works when blood sugar is elevated) Suppressing glucagon release , which reduces glucose production by the liver Slowing gastric emptying , which helps control post-meal blood sugar spikes Reducing appetite through effects on brain centres that regulate hunger, often leading to significant weight loss Because Jardiance works primarily through the kidneys and Rybelsus through multiple mechanisms involving the pancreas, liver, gut, and brain, their combined effects can provide comprehensive glucose control