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Within a substrate-aware framework, clinical surveillance may therefore include periodic assessment of (i) lean mass trajectory, (ii) micronutrient statusparticularly nutrients supporting enzymatic throughput and redox cyclingand (iii) fat-soluble vitamin indices as indirect indicators of bile-dependent absorption integrity

Despite the shared mechanisms of action, these clinical approaches vary considerably in development strategy and trial design

In the United States, over 40% of adults are obese as of the early 2020s ( [16] ), and worldwide obesity rates continue to rise

Only experienced providers understand this number, and it varies quite a bit from patient to patient