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Using a L-5-methyltetrahydrofolate instead of folic acid, and ensuring we have optimal B12 in the form of methylcobalamin, and vitamin B6 in P-5-P form are key in helping with these pathways

doi: 10.1038/s41593-021-00860-2 193 MonroeSMAndersonSFHarknessKL

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However, during MIRI, this crucial defense system is severely overwhelmed and dysregulated, rendering it incapable of counteracting the massive oxidative burst (Jiang et al., 2023)