DSIP crosses the blood-brain barrier freely an unusual property for a peptide of its size via a non-competitive, non-saturable passive mechanism whose physicochemical determinants (lipophilicity, charge, molecular weight, and protein-binding) are now well characterised
Allowing researchers to isolate satiety effects from glucose homeostasis pathways
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Steiger A, Guldner J, Hemmeter U, Rothe B, Wiedemann K, Holsboer F