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Entre los mecanismos operativos, se postulan efectos protectores de SEMA sobre el remodelado cardiaco con disminucin de la hipertrofia y la fibrosis con mejora de la funcin mitocondrial, de la funcin microvascular y la reduccin de apoptosis demostrados tanto en modelo experimental como clnico27,28, as como otros efectos metablicos relacionados con la reduccin de masa grasa (fig
Salmon JH, Rat AC, Sellam J et al (2016) Economic impact of lower-limb osteoarthritis worldwide: a systematic review of cost-of-illness studies
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Since these drugs have only been widely prescribed for a few years, longer term follow-up will be important
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