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Peripheral events, such as gut-derived antigens, molecular mimicry, or post-translationally changed -synuclein in the enteric nervous system, might trigger T-cell sensitization that travels to the CNS once the BBB is compromised [85]
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In vivo pharmacokinetic applicability of a simple and validated HPLC method for orally administered trans-resveratrol loaded polymeric nanoparticles to rats
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