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In addition, in order to compare the pharmacological efficacy of the multi-agonists with the standard treatment, subgroups of animals were orally treated with a daily dose of metformin (300 mg/kg)
This leads to the release of antimicrobial peptides, such as LL37, by stressed cells, which in turn prompts the release of DNA from both the stressed cell and the skin microbiome bacteria
Since transthyretin also operates as an amyloid-beta protein scavenger, transthyretin overexpression could prevent the formation of amyloid aggregates (114)
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Another customer with dry skin reported visible results within a week, mentioning it helped improve skin tone while leaving the skin feeling soft and comfortable
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