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Tell your doctor if you now have, or have ever had, kidney illness, Lebers hereditary optic neuropathy, or if you drink excessive amounts of alcohol, or if you have ever drunk substantial amounts of alcohol

That is the evidence gap, stated plainly: the mechanism is well-motivated and the preclinical signal is consistent, but no human study has confirmed that any of it translates to people, at any dose, by any route

One study found that lactating women taking 2-60 mg of niacin daily had milk niacin concentrations of 1.17-2.75 g/mL

(c) a reticulocyte response to B12 treatment

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