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According to product SmPCs, there is no contraindication to using macrogol-based osmotic laxatives alongside Wegovy
Wegovy followed the same path as Saxenda (also manufactured by Novo Nordisk), which has now been discontinued
But tirzepatide, despite causing significant fat loss , did not make this slowdown worse compared to placebo after adjusting for body weight and composition changes
Obici says many of her patients get confused by this because Mounjaro has a direct weight-loss counterpart: Zepbound (also tirzepatide)
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