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Lipid profile GLP-1RAs exert anti-inflammatory effects in the CV system, reduce hepatic steatosis, and lower circulating triacylglycerol and low-density lipoprotein (LDL) cholesterol levels
Semaglutide, as a GLP-1R agonist, works very similarly to GLP-1 by potentiating glucose-stimulated insulin secretion from the pancreatic -cells while suppressing glucagon secretion by pancreatic -cells [103]
It has been around since 1959, making it one of the longest-standing FDA-approved weight loss medications in the United States
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