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A part of this work was conducted in Advanced Research Infrastructure for Materials and Nanotechnology Open Facilities in Osaka University, supported by ARIM Program of the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan, Grant Number JPMXP1224 OS1059

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All authors contributed to manuscript revision, read, and approved the submitted version

Sulfonylurea drugs affect sulfonylurea receptor 1 (SUR 1), which leads to the closure of adenosine triphosphate (ATP)-dependent potassium channels, preventing potassium from leaving the cell and depolarizing the cell membrane, leading to an influx of calcium and triggering insulin release