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The study did not show a clinically meaningful change in either hormones exposure: ethinyl estradiol exposure (level) was essentially unchanged, and levonorgestrel exposure (level) increased modestly (by less than 20%), in a way that, if anything, would maintain or improve contraceptive effectiveness

Subsequently, cells were blocked in 2% BSA (Euromedex, 04-100-812-E), 0.2% Tween-20 and 1 PBS (blocking buffer) for 20 min at room temperature

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Licensed injectable GLP-1 receptor agonists such as semaglutide and dulaglutide are available for appropriate patients through NHS prescribing

In total, more than 500 muscle fibers were evaluated per sample using ImageJ software to ensure sufficient statistical assessment [2]