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Prior to the testing the drug on people with alopecia, the researchers tested two FDA-approved JAK inhibitors ruxolitinib and tofacitinib on mice with extensive hair loss from the disease, and found that the drugs effectively stopped the attack of T cells on hair follicles

Russo A, Tellone E, Barreca D, Ficarra S, Lagan G

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These conditions can affect the absorption of vitamins and nutrients, including B12

It appears to have been impactful in mice models of cardiac disease, where the life expectancy was reported to be increased by 27% compared to control animals