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Mediation Mendelian randomization analysis Mediation MR analysis was employed to elucidate the mechanistic pathways underlying the causal association between GLP-1 RAs and mood disorders

PTL conceived the study, participated in its design, and coordination, and helped to draft the manuscript

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The consequences of severe hypokalemia can be life-threatening: Cardiac arrhythmias (irregular heartbeats) Muscle weakness and paralysis Respiratory failure (breathing problems) Rhabdomyolysis (breakdown of muscle tissue) Potential cardiac arrest (heart stopping) Patients with poor nutritional status or other metabolic conditions are particularly vulnerable to this complication