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Animal studies, particularly in rodents, have shown that high-dose GLP-1 exposure can lead to pancreatic ductal proliferation and, in some cases, inflammatory changes

doi:10.1002/ange.19260391502

The letters also provide information about the circumstances under which compounded semaglutide products are allowed by law and make it clear that compounded drugs are not approved or evaluated by the Food and Drug Administration for safety and effectiveness

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