Clinically, macular edema resulting from DR can be treated with Ozurdex administered into the vitreous cavity [152]
Leptin resistance, disrupted hunger signaling, altered gut microbiome composition, and genetic predisposition all play documented roles
Safety-wise, the evidence is reassuring
When considering study drug discontinuation or use of rescue medication (trial product estimand results), the weight loss resulting from the use of oral semaglutide was up to 5 kg, while that associated with other active comparators ranged from 0.8 to 3.8 kg, and that associated with placebo ranged from 0.1 to + 0.6 kg [35,36,37,38,39,40]
These small changes are the building blocks of a life lived to the fullest