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The factors that lead to depletion of glutathione includes natural ageing process, or the external stressors that include chronic exposure to chemical toxins, cadmium exposure, alcohol use, smoking, pollution, strenuous aerobic activities, dietary factors, ultraviolet (UV) radiation exposure, tissue injury as from burns, ischemia, septic shock, surgery, drugs (such as acetaminophen and adriamycin)
The peptides physical identity is commonly summarized as follows: sequence GEPPPGKPADDAGLV, molecular formula C62H98N16O22, molecular weight approximately 1,419.56 Da, and CAS number 137525-51-0