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Q: What tests can diagnose it
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Briefly, at typical physiological GSH concentrations and pH, the reaction between ONOO - and GSH will predominantly be a two electron oxidation process leading to GSSG formation (Quijano et al., 1997)
As this occurs in a cyclic fashion, significant amounts of NADPH can be generated in proportion to the expenditure of mitochondrial ATP and NADH
Mitochondrial ROS overproduction has been indicated to donate to cardiomyocyte injury and greater myocardial injury after acute myocardial infarction (AMI) [9, 10]
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