Preclinical rodent models of postoperative ileus have been used to examine ghrelin-mimetic signaling on gastrointestinal motility (gastric emptying, intestinal transit)
These effects are primarily mediated by the inhibition of NF-B and mitogen-activated protein kinase (MAPK) pathways, both of which are associated with stress, inflammation, and apoptosis responses (10, 42)
In fact, around 85% of patients encounter this phase, which stems from a mix of factors like metabolic shifts, dosage challenges, muscle loss, hidden calories, reduced activity, hormonal changes, and natural body weight set points
Monitoring confirms these beneficial effects occur as expected
Quick Answer: No formal drug interaction exists between cannabis and Wegovy, but cannabis may counteract Wegovy's appetite-suppressing effects and compound gastrointestinal side effects, potentially compromising weight loss outcomes