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"The complex machinery of human cobalamin metabolism"

At normal therapeutic doses (up to 3,0004,000 mg/day in adults), hepatic glutathione stores are typically adequate for NAPQI neutralization and rapid regeneration

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Conversely, excessive levels of oxidants in skeletal muscle, often linked to prolonged exercise, can impair proteins critical to excitationcontraction coupling, thereby inducing muscle fatigue and diminishing the physiological advantages of ROS production during moderate-intensity exercise (58)

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