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The available X-ray crystal structures implicate histidine 571 (that arises from the opposing subunit) as being responsible for this deprotonation, as it is the only residue that is proximal to the C154-C159 pair that has the capacity to act as a general base (Figure 2)

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In this analysis, a further censoring criterion was applied so that patients were censored from follow-up on the date of switch to, or add on of, the other study drug (ie, follow-up among patients treated with DPP4 inhibitors was censored on the date of a GLP1 receptor agonist prescription, and vice versa)

Retaining the endplate has been shown to be pivotal to restrict tissue swelling and osmotic cell death

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