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GPx2 counteracts PGE2 production by dampening COX-2 and mPGES-1 expression in human colon cancer cells
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9ad), but none of these isoforms displayed a dependency in cancer cell line genetic screens (Extended Data Fig
moreover, l-ARG has been found to play a relevant positive impact on atherosclerosis, as demonstrated by two RCTs showing that administration of l-ARG improved endothelium-dependent vasodilation of brachial [55] and coronary arteries [56] in patients with angiographically reported coronary artery disease
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