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For example GST mediates the conjugation reaction of the 8,9-epoxide to the endogenous compound GSH, this essentially neutralizes its toxic potential (Fig

The HMRD in PASC pathology is a cumulative clinical outcome of several causative mechanisms comprising both SARS-CoV-2-derived virulence factors, as well as a multitude of host cellular factors and innate responses

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This complex interaction between eryptosis, oxidative stress, inflammation, and uremic toxins underscores the critical role of eryptosis in AKI pathophysiology, highlighting its potential as both a biomarker and a therapeutic target in the management of kidney injury

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