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Activating both receptors can improve insulin secretion, enhance fat metabolism and amplify appetite suppression

From its initial use in the treatment of type 2 diabetes to its expansion to 12 indications such as obesity, cardiovascular disease, chronic kidney disease, and metabolic dysfunction related fatty liver disease (MASLD), the annual sales of GLP-1 drugs exceeded 100 billion dollars, and its research and development funding reached a historical peak of 21.72 million dollars in 2025

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There are also reports of seasonal variation in thyroid function