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While semaglutide affects the brain in this way, it is generally considered safe and well-tolerated when used as prescribed by a healthcare provider

Jackson AA, Persaud C, Hall M, Smith S, Evans N, Rutter N: Urinary excretion of 5-L-oxoproline (pyroglutamic acid) during early life in term and preterm infants

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Semaglultide targets Spp1(+) microglia/macrophage to attenuate neuroinflammation following perioperative stroke