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One-way ANOVA was used to compare means of three or more groups

However, on top of the concern for survival and growth of TAM-tolerant cells, there are adverse events (AE) associated with TAM therapy, including hot flashes, increased risk of endometrial cancer, and, in rare instances, liver abnormalities (Viedma-Rodrguez et al., 2014)

However, under conditions of stress and inhibition of the electron transport chain, the enzyme works in the opposite direction by transferring electrons from NADPH to NAD + , which impairs mitochondrial antioxidant defenses and feeds more reducing equivalents into the impaired electron transport chain leading to increased electron leakage and superoxide formation [133]

The genotoxicity tolerance was improved by modulating the loss of DNA studied through comet assay and related parameters

Haluskov L et al