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MEK is a part of the MAPK signalling cascade, and MEK inhibitors (U0126) have been shown to dramatically diminish the invasiveness of MDA-MB-2311 in vitro , while selumetinib has been shown to suppress lung metastasis in xenograft models (70, 71)

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Introduction Classically, the regulation of cell death is assumed to be achieved by two main models: accidental cell death (ACD) and regulated cell death (RCD) ( In 2002, Dolma et al ( Figure 1 for a glossary of key terms in ferroptosis)