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and Sato (134, 135) observed an increase in 3-nitrotyrosine levels (a product of tyrosine nitration) in severe allergic reactions
Diabetic neuropathy Peripheral neuropathy Up to 50% of diabetic patients develop peripheral neuropathy, a type of nerve damage that may result in pain, loss of sensation, and weakness, particularly in the lower extremities (67)
Preclinical performance data are mixed
Long-term use Multiple trials suggest that 6001,200mg/day of ALA is well tolerated over extended periods
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