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While prevalence data for subclinical gut overgrowth is difficult to quantify precisely because it is underdiagnosed functional medicine practitioners report that it is among the most common root-cause findings in patients presenting with chronic fatigue, irritable bowel syndrome, and treatment-resistant mood disorders

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Garcia-Echeverria et al (2004) presented a new compound (a pyrrolo[2,3-d] pyrimidine) that although inhibiting the IGF-1R and IR TK equipotently in cell-free systems, exhibited several-fold selectivity for the IGF-1R in a cellular context and reduced the growth of IGF-1R positive fibrosarcomas in vivo

Expert Rev Clin Pharmacol 6(3):323332 Uckert S et al (2001) Phosphodiesterase isoenzymes as pharmacological targets in the treatment of male erectile dysfunction