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Thus, under asthmatic conditions, intracellular GSH levels could reflect not only the generation of reactive hydroperoxy-phospholipids by the 15LO1-PEBP1 complex, but also the compensatory levels and activity of GPX4, the availability of newly synthesized and regenerated GSH, as well as extracellular transport
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Therefore, the combined use of GLP-1 RAs with therapies targeting intrahepatic pathways, such as thyroid hormone receptor (THR-) agonists, fibroblast growth factor-21 (FGF21) analogues, and peroxisome proliferator-activated receptor (PPAR) agonists, presents a promising approach for MASH treatment
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92 In addition to the aforementioned amino acids, other amino acids play crucial roles in regulating tumor metabolism
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