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The reasonable inference is that an accurately dosed compounded equivalent should behave similarly but that is an inference, not a tested result, and the gap between them is exactly what the rest of this article is about

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It occurs when abnormal blood vessels grow beneath the retina and leak fluid or blood, damaging the central part of the retina responsible for sharp, detailed vision

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Its better to maintain a calorie deficit of around 10-15%, but allow time for your brain to reach its new set point