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doi: 10.1016/j.biopha.2019.109249 22 ZiaAFarkhondehTPourbagher-ShahriAMSamarghandianS

Gastrointestinal cytoprotection: BPC-157 has been studied extensively for its protective effects on gastric and intestinal mucosa, adding a research dimension absent from TB-500 alone

A 2020 review of case reports found that self-administered coffee enemas caused adverse effects such as: abdominal pain bloody stool rectal pain or burning proctocolitis, or inflammation of the rectal lining colitis, or inflammation of the colon The review also noted three deaths following coffee enema

This is imped widespread acceptance among regulators and healthcare providers

None of the three compounds have safety data in this context