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Noor et al., Targeting Uch-L1 and Fbx2 in AD Uch-L1 Regulates the CREB Signaling Pathway in AD UPS dysfunction slows or stops the degradation of many proteins, including misfolded proteins, and results in protein aggregation in the cytoplasm, nucleus and extracellular space of neurons

8 It is required for hepatic GSH synthesis and may be derived from methionine, which serves as a major source of cysteine, via the trans-sulfuration pathway of the liver

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