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5) can be related with the fatty acid compositional changes in lipoprotein fractions (table 4, group 6 vs

Q.23 Administration of primaquine causes severe hemolytic anemia because it (A) increases the demand for NADPH to a level that cells cant meet (B) decreases the demand for NADPH (C) inactivates glutathione peroxidase of erythrocytes (D) increases reduced glutathione level of erythrocytes Primaquine administration causes severe hemolytic anemia primarily in individuals with G6PD deficiency due to oxidative stress overwhelming cellular defenses

doi: 10.21037/atm-22-2382 221 LiangYLinJHuangBWengMZhenTYangLet al

Brigelius-Flohe R, Maiorino M

Mitochondrial glutamate generated via these catabolic pathways can be exported from mitochondria to the cytosol through the SLC25A18 and SLC25A22 transporters 21 , and cytosolic glutamate then participates in the biosynthesis of glutathionea tripeptide comprising glutamate, cysteine, and glycineand NEAAs (alanine, proline, aspartate, asparagine, and arginine) and is used as an exchange factor for importing extracellular cystine via SLC7A11