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Novo Nordisks revenues from Ozempic and Wegovy have reached and likely exceeded $20 billion annually across their type 2 diabetes and obesity indications

Furthermore, endogenous GLP-1 receptor signaling is crucial for the adaptive proliferative response of islets to metabolic stress and pancreatic injury (Xu et al., 1999)

Pregnant or breastfeeding Severe gastrointestinal problems

According to the Zepbound prescribing information, tirzepatide commonly causes nausea (24-29%), diarrhea (18-24%), vomiting (8-11%), constipation (16-17%), and abdominal pain (10-15%), with rates increasing at higher doses