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Discussion First-line treatment of CSU with H 1 -antihistamines often requires dose titration up to four times the standard dose, as recommended in guidelines [11]

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Additive effect on kidney outcomes including macroalbuminuria was also expected from AMPLITUDE-O substudy, however, additive effect of semaglutide and SGLT2i on the composite kidney outcomes without macroalbuminuria was not indicated in the FLOW substudy [50]