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The elevation in plasma GSSG without a concomitant decrease in plasma fGSH suggests that the children with ASD/NoMD are, in general, under higher extrinsic or intrinsic oxidative stress

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In the intrinsic pathway, ROS-mediated mitochondrial damage is the core triggering factor, while pro-inflammatory factors not only directly induce apoptosis through the extrinsic pathway but also exacerbate ROS accumulation by inhibiting the activity of mitochondrial respiratory chain complexes, accelerating the progression of the intrinsic apoptotic pathway

Risk of hepatotoxicity in patients with gout treated with febuxostat or benzbromarone: a propensity score-matched cohort study

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